Figure 7
The pathways for miRNA-155 to mediate ATO resistance in A549R cells. miR-155 in lung cancer cells activates Nrf2 that subsequently upregulates the expression of antioxidant genes i.e., HO-1 and NQO1 in A549R cells (subpathway 1). This further increases the antioxidant capacity and promotes survival of the lung cancer cells. On the other hand, miR-155 reduces the ratio of Bax/Bcl-2 and suppressed apoptosis and cell death (subpathway 2). All these result in increased colony formation and migration, thereby leading to a high level of cellular resistance to ATO.
