Figure 2
From: GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory
GSK-3β deletion in DG induces spatial and fear memory deficits. (a) GSK-3β deletion in DG excitatory neurons does not change the latency to find the hidden platform during 6 days Morris water maze (MWM) training. (b,c) GSK-3β deletion induces memory deficits shown by the decreased time in previous target quadrant and the crossings in the platform region measured at day 8 by removed the platform (Vector, n = 10; Cre, n = 8). (d) The schematic representation of contextual fear memory test. (e) No change of freezing time was detected in GSK-3β deletion during the contextual fear training test. (f) The percentage time of freezing was remarkably decreased during the contextual memory test carried out in the next day (Vector, n = 10; Cre, n = 8). Data were presented as mean ± s.e.m. Two–way repeated-measures ANOVA with Huynh-Feldt-Lecoutre correction for panels (a) and (e); unpaired t test for panels (b, c, and f). *P < 0.05, ***P < 0.001 versus Vector. The absence of asterix indicates that the difference is not significant.
