Table 3 Parameter estimates for the eight subjects included in the study. Values are given as mean ± standard error, unless otherwise stated.
From: Bridging the gap between measurements and modelling: a cardiovascular functional avatar
Parameter | Description (units) | Literature values | Estimated values (n = 8) |
|---|---|---|---|
Pulmonary venous system | |||
Ppu | Pulmonary capillary pressure (mmHg) | 7.4 (Sun et al.14) | 10.8 ± 0.68 |
Rpva | Resistance of pulmonary veins (mmHg·s/mL) | 2·10−3 (Sun et al.14) | 2·10−3 |
Lpva | Inertance of pulmonary veins (mmHg· s2/mL) | 5·10−4 (Sun et al.14) | 5·10−4 |
Rpvca | Viscoelastic resistance of pulmonary capillaries and veins (mmHg·s/mL) | 0.01 (Sun et al.14) | 0.01 |
Cpvca | Capacitance of pulmonary capillaries and veins (mL/mmHg) | 4 (Sun et al.14) | 4 |
Rpua | Resistance of pulmonary capillaries (mmHg·s/mL) | 0.01 (Sun et al.14) | 0.01 |
Heart parameters | |||
Left atrium (LA) | |||
Ks,LA | Source resistance coefficient of the LA (s/mL) | 10·10−9 (Mynard et al.15) | 12.26·10−9 ± 1.92·10−9 |
Emin,LA | Minimal elastance of the LA (mmHg/mL) | 0.08 (Mynard et al.15) | 0.11 ± 3.5·10−3 |
Emax,LA | Maximal elastance of the LA (mmHg/mL) | 0.17 (Mynard et al.15) | 0.15 ± 7.1·10−3 |
V0,LA | Unstressed volume of the LA (mL) | 3 (Mynard et al.15) | 2.68 ± 0.43 |
m1,LA | Contraction rate constant of the LA (−) | 1.32 (Mynard et al.15) | 1.22 ± 0.14 |
m2,LA | Relaxation rate constant of the LA (−) | 13.1 (Mynard et al.15) | 12.9 ± 1.96 |
α1,LA | Systolic time constant of the LA (−) | 0.11 (Mynard et al.15) | 0.1 ± 0.04 |
α2,LA | Diastolic time constant of the LA (−) | 0.18 (Mynard et al.15) | 0.2 ± 0.02 |
Rvisc,LA | Viscous loss resistance for the LA (mmHg·s/mL) | 1·10−4 (Mynard et al.15) | 1.37·10−4 ± 1.77·10−5 |
OnsetLA | Onset of contraction of the LA (s) | 0.85 (Mynard et al.15) | 0.8 ± 0.01 |
Left ventricle (LV) | |||
Ks,LV | Source resistance coefficient of the LV (s/mL) | 4·10−9 (Mynard et al.15) | 2.93·10−9 ± 4.35·10−10 |
Emin,LV | Minimal elastance of the LV (mmHg/mL) | 0.08 (Mynard et al.15) | 0.09 ± 7.1·10−3 |
Emax,LV | Maximal elastance of the LV (mmHg/mL) | 3 (Mynard et al.15) | 1.97 ± 0.17 |
V0,LV | Unstressed volume of the LV (mL) | 10 (Mynard et al.15) | 11.46 ± 2.03 |
m1,LV | Contraction rate constant of the LV (−) | 1.32 (Mynard et al.15) | 1.67 ± 0.12 |
m2,LV | Relaxation rate constant of the LV (−) | 27.4 (Mynard et al.15) | 33.92 ± 1.2 |
α1,LV | Systolic time constant of the LV (−) | 0.269 (Mynard et al.15) | 0.4 ± 0.03 |
α2,LV | Diastolic time constant of the LV (−) | 0.452 (Mynard et al.15) | 0.42 ± 0.01 |
Rvisc,LV | Viscous loss resistance for the LV (mmHg·s/mL) | 1·10−4 (Mynard et al.15) | 1.69·10−4 ± 1.62·10−5 |
OnsetLV | Onset of contraction of the LV (s) | 0 (Mynard et al.15) | −0.04 ± 8.8·10−3 |
Mitral valve | |||
Rmv | Resistance of the mitral valve (mmHg·s/mL) | 3.75·10−3 (Sun et al.14) | 4.52·10−3 ± 7.46·10−4 |
Lmv | Inertance of the mitral valve (mmHg·s2/mL) | 2·10−4 (Sun et al.14) | 7·10−4 ± 4.6·10−5 |
Aortic valve | |||
EOAav | Effective orifice area of the aortic valve (cm2) | 1.69 (Garcia et al.16) | 2.65 ± 0.54 |
Aao | Cross sectional area of the aorta (cm2) | 5 (Olufsen et al.62) | 6.09 ± 1.27 |
Lav | Inertance of the aortic valve (mmHg· s2/mL) | 4·10−4 (Sun et al.14) | 2.74·10−4 ± 4.6·10−4 |
Systemic arterial system | |||
Raa | Resistance of the ascending aorta (mmHg·s/mL) | 0.06 ± 0.03 | |
Laa | Inertance of the ascending aorta (mmHg· s2/mL) | 1.01·10−4 ± 1.06·10−6 | |
Raav | Viscoelastic resistance for Caa (mmHg·s/mL) | 0.01 (Sun et al.14) | 6.11·10−3 ± 1.8·10−3 |
Caa | Capacitance of the ascending aorta (mL/mmHg) | 0.13 ± 0.01 | |
Rpsa | Proximal peripheral resistance for the supra aortic vessels (mmHg·s/mL) | — | 0.05 ± 3.5·10−3 |
Rdsa | Distal peripheral resistance for the supra aortic vessels (mmHg·s/mL) | 3.9 (Heldt et al.19) | 3.47 ± 0.56 |
Cpsa | Peripheral compliance for the supra aortic vessels (mL/mmHg) | 0.6 (Liang et al.17) | 0.49 ± 0.03 |
Rpia | Proximal peripheral resistance for the intercostal arteries (mmHg·s/mL) | — | 0.05 ± 3.5·10−3 |
Cpia | Peripheral compliance for the intercostal arteries (mL/mmHg) | 0.93 (Liang et al.17) | 0.13 ± 0.03 |
Rdia | Distal peripheral resistance for the intercostal arteries (mmHg·s/mL) | 3 (Heldt et al.19) | 8.37 ± 1.18 |
Rda | Resistance of the abdominal aorta (mmHg·s/mL) | 0.07 ± 0.01 | |
Lda | Inertance of the abdominal aorta (mmHg· s2/mL) | 1.7·10−3 ± 3.46·10−4 | |
Rdav | Viscoelastic resistance for Cda (mmHg·s/mL) | 0.01 | 5.83·10−3 ± 6.36·10−4 |
Cda | Capacitance of the abdominal aorta (mL/mmHg) | 0.24 ± 0.04 | |
Rpda | Proximal peripheral resistance (mmHg·s/mL) | — | 0.05 ± 6.4·10−3 |
Rdda | Distal peripheral resistance (mmHg·s/mL) | 0.91 ± 0.05 | |
Cda | Peripheral compliance (mL/mmHg) | 2(Sun et al.14) | 0.96 ± 0.11 |
Other parameters | |||
Tb | Duration of the cardiac cycle (s) | — | 0.9 ± 0.05 |
ρ | Density of blood (g/mL) | 1.06 | 1.06 |