Table 4 Estimated parameter values and the associated 95% confidence intervals [σ−, σ+] derived from the profile likelihood for subject 1.
From: Bridging the gap between measurements and modelling: a cardiovascular functional avatar
Parameter | Estimated value | PL-based confidence interval | Identifiability | |
|---|---|---|---|---|
σ− | σ+ | |||
Pulmonary venous system | ||||
Ppu | 12 | 11.07 | 12.92 | Identifiable |
Heart parameters | ||||
Left atrium (LA) | ||||
Ks,LA | 1.19·10−8 | −∞ | ∞ | Structurally non-identifiable |
Emin,LA | 0.12 | 0.09 | 0.14 | Identifiable |
Emax,LA | 0.15 | 0.15 | 0.2 | Identifiable |
V0,LA | 3.22 | — | — | Practically non-identifiable |
m1,LA | 1.29 | — | — | Practically non-identifiable |
m2,LA | 8.30 | — | — | Practically non-identifiable |
α1,LA | 0.11 | — | — | Practically non-identifiable |
α2,LA | 0.15 | — | Practically non-identifiable | |
Rvisc,LA | 8.46·10−5 | −∞ | ∞ | Structurally non-identifiable |
OnsetLA | 0.75 | 0.75 | 0.85 | Identifiable |
Left ventricle (LV) | ||||
Ks,LV | 2.09·10−9 | −∞ | ∞ | Structurally non-identifiable |
Emin,LV | 0.10 | 0.06 | 0.14 | Identifiable |
m1,LV | 1.66 | 1.48 | 1.82 | Identifiable |
m2,LV | 35.89 | 27.54 | 49.29 | Identifiable |
α1,LV | 0.41 | 0.30 | 0.50 | Identifiable |
α2,LV | 0.48 | 0.38 | 0.58 | Identifiable |
Rvisc,LV | −∞ | ∞ | Structurally non-identifiable | |
OnsetLV | −0.06 | −0.07 | −0.06 | Identifiable |
Mitral valve | ||||
Rmv | 6.26·10−3 | — | — | Practically non-identifiable |
Lmv | 5.9·10−4 | 2.67·10−4 | — | Practically non-identifiable |
Aortic valves | ||||
Lav | 1.64·10−4 | — | 1.24·10−3 | Practically non-identifiable |
Systemic arterial system | ||||
Raa | 0.08 | 0.06 | 0.13a | Practically non-identifiable |
Laa | 1·10−4 | — | 1.46·10−3 | Practically non- identifiable |
Raav | 5·10−3 | −∞ | ∞ | Structurally non-identifiable |
Caa | 0.11 | 0.02 | 0.21 | Identifiable |
Cpsa | 0.31 | 0.14 | 0.31 | Identifiable |
Cpia | 0.06 | − | 0.29 | Practically non-identifiable |
Rda | 0.08 | 0.05 | 0.13a | Practically non-identifiable |
Lda | 2.15·10−3 | 1.17·10−3 | — | Practically non-identifiable |
Rdav | 5·10−3 | −∞ | ∞ | Structurally non-identifiable |
Cda | 0.21 | 0.07 | 0.34 | Identifiable |
