Table 3 The downregulated genes involved in immune-related pathways in primary monocytes of XLA patients compared to healthy subjects.

From: Transcriptome profiling of monocytes from XLA patients revealed the innate immune function dysregulation due to the BTK gene expression deficiency

Pathway Terms

P-value

Adj.P-value

Gene Name

Fc gamma R-mediated phagocytosis

1.10E-07

2.60E-06

FCGR2A, ASAP1, GAB2, DOCK2, DNM1L, INPP5D, MAPK1, MAP2K1, PAK1, PIKFYVE, PIK3CG, PIK3R5, PLCG1, PRKCB, PRKCE, PTPRC, SYK, LYN, VASP, VAV3, PIK3R1, RAF1, AKT2

Chemokines signaling pathway

4.70E-07

9.30E-06

CXCL16, CXCR4, CXCR1, CXCR2, JAK2, ROCK2, ADCY6, ADCY7, ADCY9, ADRBK2, DOCK2, FOXO3, GRB2, GNB4, GNG12, GNG2, MAPK1, MAP2K1, NRAS, PAK1, PIK3CG, PIK3R1, PIK3R5, PRKCB, PRKX, STAT2, STAT5B, ROCK1, SOS1, SOS2, BRAF, VAV3

Toll-like receptors signaling pathway

3.10E-06

4.30E-05

TLR1, TLR5, TLR2, TLR4, TLR6, TLR7, TBK1, IKBKE, JUN, MAPK1, MAP2K1, MAP2K4, MYD88, PIK3CG, PIK3R1, PIK3R5, FOS

MTOR signaling pathway

5.20E-05

3.80E-04

MTOR, RICTOR, HIF1A, MAPK1, PIK3CG, PIK3R1, PIK3R5, RPS6KA3, TSC1, ULK2, BRAF

Jak-STAT signaling pathway

1.20E-04

7.10E-04

CREBBP, CBL, EP300, JAK1, JAK2, CSF2RB, GRB2, IL10RA, IL13RA1, IL6R, IL6ST, PIK3CG, PIK3R1, PIK3R5, PRLR, STAT2, STAT5A, STAT5B, SOS1, SOS2, SOCS4, SOCS7

MAPK signaling pathway

4.30E-04

2.10E-03

RAPGEF2, ATF2, DUSP1, DUSP6, FLNB, GRB2, GNA12, GNG12, HSPA1A, JUN, MAPK1, MAP2K1, MAP2K4, MAP3K1, MAP4K4, NRAS, PAK1, PRKCB, PRKX, RPS6KA3, SOS1, SOS2, TGFBR1, FOS, BRAF

ErbB signaling pathway

5.10E-04

2.40E-03

CBL, EREG, GRB2, JUN, MTOR, MAPK1, MAP2K1, MAP2K4, NRAS, PAK1, PIK3CG, PIK3R, PIK3CG, PIK3R, PIK3R5, PLCG1, PRKCB, STAT5A, STAT5B, SOS1, SOS2, ABL2, BRAF

Insulin signaling pathway

8.30E-04

3.80E-03

CBL, GRB2, INPP5D, IRS2, MTOR, MAPK1, MAP2K1, NRAS, PDE3B, PIK3CG, PIK3R1, PIK3R5, PRKCI, PRKX, PTPRF, SOS1, SOS2, SOCS4, TSC1, BRAF

Endocytosis

1.00E-03

4.50E-03

ARAP2, ASAP1, ACAP2, CBL, DNAJC6, EHD3, IQSEC1, RAB11, FIP1, ADRBK2, CXCR4, CLTCL1, DNM1L, EPN2, HSPA1A, CXCR1, CXCR2, LDLR, NEDD4, PIKFYVE, PRKCI, RNF41, SMAP2, TGFBR1, VPS36

Regulation of actin cytoskeleton

2.20E-03

9.60E-03

IQGAP1, IQGAP2, ARHGEF12, ROCK2, ACTN1, CYFIP1, FGFR1, FN1, GNA12, GNA13, GNG12, ITGA4, ITGAV, ITGB1, MAPK1, MAP2K1, NRAS, PAK1, PIKFYVE, PIK3CG, PIK3R1, PIK3R5, PPP1R12A, ROCK1, SSH2, SOS1, SOS2, BRAF, VAV3

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