Figure 3 | Scientific Reports

Figure 3

From: PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity

Figure 3

Cell death in microgravity is majorly through apoptosis. The box plot for the AnnexinV FITC & PI staining for DLD1 (a), HCT116 (d) and SW620 (g) shows that major cell death during SM is induced through apoptosis. The lighter boxes represent control populations and darker ones represent SM cell populations. The data is represented as mean with data range. ****P < 0.0001, **P < 0.005, *P < 0.05 statistical analysis using two way annova. The dot plot clearly shows the cells are Annexin V FITC and PI positive cells under SM for all cell lines tested (c,f,i) compared to control cells (b,e,h).

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