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Figure 5

From: Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma

Figure 5

Effect of hepatocyte and myeloid specific Adam17 deletion on glucose metabolism and liver steatosis after 16 weeks of HFD. (A) Fasting blood glucose levels (n = 20 per group) and insulin levels (n = 6 per group). (B) IPGTT and ITT (n = 20 per group). (C) ELISA of serum TNF-α; (D) representative sections (×4 and ×10 magnification) of liver stained with H&E and ORO and quantification of the area occupied by lipid in ORO staining and (E) liver cholesterol content (n = 8 per group). (*p < 0.05, **p ≤ 0.02, ***p < 0.0005, ****p < 0.0001, φ = 0.0641; one-way ANOVA with Dunnett’s Multiple Comparison Test, data are means ± SEM).

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