Figure 3 | Scientific Reports

Figure 3

From: CDK5 Regulatory Subunit-Associated Protein 1-like 1 Negatively Regulates Adipocyte Differentiation through Activation of Wnt Signaling Pathway

Figure 3

Suppression of PPARγ expression by CDKAL1 contributes to the anti-adipogenic action of CDKAL1. (a,b) Time course of gene expression levels of early adipogenic regulators, C/EBPβ and C/EBPδ (a) and late regulators, PPARγ and C/EBPα (b) during adipocyte differentiation of 3T3-L1 cells expressing CDKAL1 (n = 3). (c,d) Effect of PPARγ agonist pioglitazone on lipid accumulation (c) and gene expression (d) in differentiated 3T3-L1 cells expressing CDKAL1 (n = 3). (e,f) Effect of coexpression of PPARγ on lipid accumulation (e) and gene expression (f) in differentiated 3T3-L1 cells expressing CDKAL1 (n = 3, **p < 0.005, ***p < 0.0005 vs control group by Dunnett’s test).

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