Figure 6
From: Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats
A proposed underlying mechanism for fat-induced oxidation/inflammation/aging. ROS, reactive oxygen species; FA: fatty acids; n-3: n-3 fatty acids; n-6: n-6 fatty acids; SFA: saturated fatty acid; TLR: toll- like receptor; NF-ĪŗB: nuclear transcription factor ĪŗB; FOXO 1: fork head box O 1; Pro-IL-1Ī²: pro-interleukin 1Ī²; MnSOD: Mn superoxide dismutase; CAT: catalase; IL-6: interleukin 6; TNF-Ī±: tumor necrosis factor Ī±; IL-1Ī²: interleukin 1Ī²; purple line indicates the CASP-1 mediated pathway; green line indicates the insulin-induced pathway; red line indicates TNF-Ī±, cellular apoptosis and senescence pathways which increase ROS production; blue dot line indicates auto-activation loop induced by IL-6 and IL-1Ī².
