Table 2 Serological and virological data of ZIKV- and DENV-infected patients.

From: Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells

Patient ID (Gender)

Days after symptoms onset

Sample

ZIKV Real Time RT-PCRa

DENV Real Time RT-PCRb

CHIKV Real Time RT-PCRc

Anti ZIKV IgGd

Anti ZIKV IgMd

Anti DENV IgGd

Anti DENV IgMd

Anti CHIKV IgGd

Anti CHIV IgMd

Pt1 (F)

3

Serum

Negative

Negative

Negative

1:320

<1:20

1:640

<1:20

<1:20

<1:20

Urine

Positive

Negative

ND

ND

ND

ND

ND

ND

ND

Saliva

Positive

Negative

ND

ND

ND

ND

ND

ND

ND

Pt2 (F)

2

Serum

Positive

Negative

Negative

<1:20

<1:20

<1:20

<1:20

<1:20

<1:20

Urine

Positive

Negative

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Pt3e (F)

9

Serum

Negative

Negative

Negative

1:160

1:80

1:40

<1:20

<1:20

<1:20

Urine

Positive

Negative

ND

ND

ND

ND

ND

ND

ND

Pt4 (M)

9

Serum

Negative

Negative

Negative

1:80

1:160

1:20

<1:20

<1:20

<1:20

Urine

Positive

Negative

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Pt5 (F)

9

Serum

Positive

Negative

Negative

1:160

1:80

1:160

<1:20

<1:20

<1:20

Urine

Positive

Negative

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Pt6 (F)

6

Serum

Negative

Negative

Negative

1:20

1:80

<1:20

<1:20

<1:20

<1:20

Urine

Positive

Negative

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Pt7 (F)

9

Serum

Negative

Negative

Negative

1:160

1:80

<1:20

<1:20

<1:20

<1:20

Urine

Positive

Negative

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Pt8 (M)

9

Serum

Negative

Positive

Negative

<1:20

<1:20

Weak reactivity

1:40

<1:20

<1:20

Urine

Negative

Positive

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Pt9 (M)

4

Serum

Negative

Positive

Negative

<1:20

<1:20

<1:20

<1:20

<1:20

<1:20

Urine

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Pt10 (M)

5

Serum

Negative

Positive

Negative

<1:20

1:40

1:40

1:80

<1:20

<1:20

Urine

Negative

Positive

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Pt11 (F)

5

Serum

Negative

Positive

Negative

<1:20

<1:20

<1:20

Weak reactivity

<1:20

<1:20

Urine

Negative

Positive

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Positive

ND

ND

ND

ND

ND

ND

ND

Pt12 (F)

4

Serum

Negative

Positive

Negative

<1:20

<1:20

1:40

<1:20

<1:20

<1:20

Urine

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

Saliva

Negative

Negative

ND

ND

ND

ND

ND

ND

ND

  1. DENV: dengue virus; ZIKV: Zika virus; RT-PCR: Reverse transcription polymerase chain reaction; ND: not done. aZIKV specific Real Time RT-PCR39. bCDC DENV-1–4 Real-Time RT-PCR Assay for Detection and Serotype Identification of Dengue Virus38. cCHIKV Real-Time RT-PCR Assay targeting the E1 structural protein40. dIgG and IgM indirect immunofluorescence assay Euroimmun Flavivirus Mosaic 2. Reference values (titre): <1:20 = negative; ≥1:20 = positive. eThis patient is vaccinated against Yellow Fever.
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