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Figure 1

From: Differentiating malignant from benign thyroid nodules with indeterminate cytology by 99mTc-MIBI scan: a new quantitative method for improving diagnostic accuracy

Figure 1

Fifty-two year-old woman with a single nodule located in the right lobe. The nodule (35 mm in maximum diameter) presented a 4B pattern at US (TI-RADS classification). (A) 99mTc-pertechnetate (111 MBq) thyroid scintigraphy showed a well defined cold area in the lower third of the right lobe, corresponding to the US nodule. Cytopathological findings were conclusive for a class IV lesion according to the Bethesda system. (B,C) 99mTc-MIBI (370 MBq) thyroid scintigraphy obtained 10 (early) and 60 (late) minutes after tracer administration. Visual MIBI analysis showed an moderate nodular tracer uptake on early image that decreased on late image. (D) MIBI quantitative analysis was obtained by drawing ROIs according to WOind method. (E) MIBI quantitative analysis was obtained by drawing ROIs according to R.I. method. Calculated WOind and R.I. were −33% and 6.6, respectively. The patient underwent total-thyroidectomy with final histology diagnosis consistent benign non-oncocytic adenoma.

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