Figure 3

Metabolic networks involving in insulin, PI3K-Akt, AMPK, MAPK, mTOR, FoxO, and PPAR signaling pathways. Green ovals represent proteins involved in pathways; pink ovals (rectangles) represent the differentially expressed proteins (genes) identified in this study; the 12 genes in ceRNA networks are marked in red font, of these, BMAL1, ECM, IGF1R, NGFR, Activin, FGFR, PYK, SHP, S1P1, OATs, and PP2A protein in the networks respectively encoded by ARNTL, COL6A1, IGF1R, NGFR, INHBE, FGFR4, PKLR, NR0B2, S1PR1, SLC22A7 and PPP2R2B genes, and the remaining FADS2 gene is in the pink rectangles.