Figure 2
Comparison of the outputs between PRC and weighted UniFrac distance based dbPRC. (A) Structure of synthetic community dataset used as input for PRC ordination analyses. Please refer to phylogenetic tree in Fig. 1A for definitions of species codes. (B) and (C) Principal response curves plots for PRC (panel B) and weighted UniFrac distance-based dbPRC (panel C) analyses. Genus weights contributing to each statistical model are shown on the right side of each panel. (D) wUF-dbPRC analysis of genus level community structure in three patients with Clostridium difficile associated disease (CDAD) undergoing fecal microbiota transplantation (original dataset was published by Shankar et al.29). Each curve corresponds to a different individual as shown; genus weights are provided in the right side panel. Initial time point corresponds to community structure prior to FMT, all other time points represent days after FMT procedure, which was carried out at time 0.
