Table 3 Association between genetic risk score from the 13 human height genetic loci and FSS risk

From: Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan

Weighted genetic risk score (wGRS) quartile

FSS (%)

Controls (%)

OR

95% CI

P value

N = 978

N = 1129

N (%)

N (%)

Q1

144 (14.7)

412 (36.5)

Ref.

Ref.

Ref.

Q2

199 (20.3)

282 (25.0)

2.02

1.55–2.63

<0.001

Q3

254 (26.0)

278 (24.6)

2.61

2.03–3.37

<0.001

Q4

381 (39.0)

157 (13.9)

6.94

5.32–9.06

<0.001

Cochran-Armitage Trend Test

    

<0.001

  1. Abbreviations: FSS, familial short stature; OR, odds ratio; CI, confidence interval; Ref., reference.
  2. The 13 human height genetic loci and the respective risk genotypes were shown in Table S3.
  3. The controls were the individuals whose body height was 75% above the general population in Taiwan.
  4. Weighted genetic risk score quartile 1 (Q1): 0 < wGRS <= 11.88; Weighted genetic risk score quartile 2 (Q2): 11.88 < wGRS <= 13.50; Weighted genetic risk score quartile 3 (Q3): 13.50 < wGRS <= 15.05; Weighted genetic risk score quartile 4 (Q4): 15.05 < wGRS.
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