Table 1 Comparison of gender, age, and age at onset distribution of the family samples with extreme and less contrast in the age at onset.
From: Genetic loci associated with an earlier age at onset in multiplex schizophrenia
Extreme contrast in the AAO | Less contrast in the AAO | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All | Earliest AAO | Latest AAO | P-value | All | Earlier AAO | Later AAO | P-value | ||||||||
Probands | n = 185 | n = 94 | n = 91 | n = 290 | n = 132 | n = 158 | |||||||||
Male, n (%) | 117 | (63%) | 53 | (56%) | 64 | (70%) | 0.06 | 192 | (66%) | 87 | (66%) | 105 | (66%) | 1 | |
Age, mean (SD) | 35.0 | (8.4) | 30.2 | (7.5) | 39.9 | (6.0) | <0.0001 | 35.1 | (7.4) | 32.2 | (7.1) | 37.6 | (6.6) | <0.0001 | |
AAO, mean (SD) | 23.7 | (9.2) | 15.1 | (1.6) | 32.6 | (3.7) | <0.0001 | 23.1 | (5.8) | 18.6 | (2.4) | 26.8 | (5.0) | <0.0001 | |
Co-affected siblings | n = 181 | n = 90 | n = 91 | ||||||||||||
Male, n (%) | 111 | (61%) | 57 | (63%) | 54 | (59%) | 0.64 | ||||||||
Age, mean (SD) | 34.8 | (8.6) | 30.6 | (7.5) | 38.9 | (7.6) | <0.0001 | ||||||||
AAO, mean (SD) | 21.4 | (4.8) | 19.6 | (3.4) | 23.1 | (5.3) | <0.0001 | ||||||||
Parents | n = 288 | n = 156 | n = 132 | ||||||||||||
Male, n (%) | 127 | (44%) | 73 | (47%) | 54 | (41%) | 0.34 | ||||||||
Age, mean (SD) | 63.1 | (9.2) | 59.3 | (8.7) | 67.7 | (7.5) | <0.0001 | ||||||||
Affected, n (%) | 21 | (7.3%) | 13 | (8.3%) | 8 | (6.1%) | 0.50 | ||||||||
AAO, mean (SD) | 32.9 | (11.0) | 28.8 | (8.7) | 43.0 | (14.8) | 0.02 | ||||||||
