Table 2 Multivariable linear regression analyses between dietary acrylamide intake and changes of MMSE at the 4^th year follow-up among Chinese elderly men and women.

	Model 1 (crude)	P	Model 2 (full adjustment)	P
MMSE 4-year change	β (95% CI)		β (95% CI)
Men (n = 723)	−0.650 (−1.908, 0.609)	0.311	−1.519 (−3.176, 0.138)	0.072
Women (n = 1809)	−0.313 (−1.085, 0.458)	0.426	−0.292 (−1.320, 0.737)	0.578
Both men and women(n = 2533)	−0.897 (−1.548, −0.245)	0.007	−0.664 (−1.323, −0.005)	0.048
Participants with MMSE ≥ 18
Men (n = 718)	−0.577 (−1.842, 0.686)	0.371	−1.443 (−3.098, 0.211)	0.087
Women (n = 1709)	−0.450 (−1.229, 0.328)	0.257	−0.631 (−1.665, 0.402)	0.231
Both men and women (n = 2427)	−0.942 (−1.598, −0.286)	0.005	−0.820 (−1.486, −0.154)	0.016
MMSE 4-year % change
Men (n = 723)	−2.346 (−7.306, 2.614)	0.353	−3.385 (−8.368, 1.597)	0.183
Women (n = 1809)	−1.749 (−5.327, 1.830)	0.338	−1.667 (−5.249, 1.895)	0.357
Both men and women (n = 2532)	−4.084 (−6.986, −1.182)	0.016	−2.870 (−0.6730, 0.991)	0.145
Participants with MMSE ≥ 18
Men (n = 580)	−3.792 (−9.403, 1.818)	0.185	−7.698 (−14.943, −0.452)	0.037
Women (n = 1387)	−1.862 (−7.540, 3.816)	0.207	−1.862 (−7.540, 3.816)	0.520

Dietary acrylamide intakes were log₁₀ transformed. Multivariable linear regression models were adjusted for age (y), sex (not included for gender specific analysis), education, income, physical activity (PASE total scores), body mass index (kg/m²), medical history of hypertension (yes/no), diabetes (yes/no), and coronary heart disease (CHD) (yes/no), dietary intake of carbonhydrate (g %kcal), fish (g/week), fruit and vegetables (g/1000 kcal), fiber (g/d) and isoflavones (mg/d), alcohol drinking (g/day), tea drinking (ml/wk), total AHA scores. Total AHA scores were estimated based on the adherence index of American Heart Association on dietary and life style recommendations. MMSE: questionnaire for Mini-Mental State Exam.

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