Figure 2 | Scientific Reports

Figure 2

From: Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders

Figure 2The alternative text for this image may have been generated using AI.

Serum concentrations of PAI-1 and BDNF and BDNF/proBDNF ratio in patients with different disorders and HCs. (a) PAI-1serum concentrations in patients with different disorders and HCs. (b) BDNF serum concentrations in patients with different disorders and HCs. (c) The value of BDNF/proBDNF in patients with different disorders and HCs. Abbreviations: SZ, schizophrenia; MDD, major depressive disorder; BM, bipolar mania; BD, bipolar depression; PD, panic disorder; HCs, healthy controls; PAI-1, plasminogen activator inhibitor-1; BDNF, brain-derived neurotrophic factor. Compared with BD group by Kruskal-Wallis test followed by Bonferroni test, *P < 0.05, **P < 0.01. Several extreme values which higher than three standard deviations were removed out from PAI-1 and the value of BDNF/proBDNF. After removing out the extreme values, the remaining number of cases showed as follows: PAI-1 (34 SZ, 30 MDD, 30 BM, 22 BD, 29 PD and 30 HCs) and BDNF/proBDNF (32 SZ, 28 MDD, 29 BM, 21 BD, 28 PD and 28 HCs).

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