Table 1 Comparative plasma pharmacokinetic parameters after i.v. injection of free TMZ and TMZ-LfNPs with an equivalent TMZ dose of 10 mg kg−1 in mice (n = 3).

From: Overcoming blood brain barrier with a dual purpose Temozolomide loaded Lactoferrin nanoparticles for combating glioma (SERP-17-12433)

Parameters

TMZ

TMZ-LfNPs

T1/2 (min)

68 ± 2.13

360 ± 70.86

MRT (min)

88 ± 7.4

367 ± 18.33

AUC (min)*(µg ml−1)

4639.66 ± 109.24

10998 ± 754

  1. T1/2 - elimination half-life of drug, MRT- mean residence time of drug in the plasma, AUC-The area under curve,
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