Table 3 Patients and tumours histopathological analysis.
From: Establishment of patient derived xenografts as functional testing of lung cancer aggressiveness
All PDX | PDX p > 10* | ||||
|---|---|---|---|---|---|
Human n = 27 | Mouse (p < 10) n = 27 | Human n = 10 | Mouse (p < 10) n = 10 | Mouse (p > 10) n = 10 | |
Diagnosis(1) | |||||
ADC | 20 | 20 | 9 | 9 | 9 |
SCLC | 4 | 4 | 1 | 1 | 1 |
SCC | 3 | 3 | 0 | 0 | 0 |
All ADC | PDX > 10 (ADC) | ||||
Human n = 20 | Mouse (p < 10) n = 20 | Human n = 9 | Mouse (p < 10) n = 9 | Mouse (p > 10) n = 9 | |
Pattern (1) | |||||
SOLID | 12 | 11 | 6 | 7 | 8 |
TRABECOLAR | 1 | 0 | NA | NA | NA |
LEPIDIC | 3 | 0 | 3 | 0 | 0 |
SPINDLE CELLS | 2 | 4 | 1 | 1** | 1** |
ACINAR | 10 | 7 | 4 | 3 | 2 |
CRIBRIFORM | 11 | 7 | 6 | 5 | 4 |
MUCINOUS | 1 | 2 | 1 | 2 | 2 |
PAPILLAR | 8 | 2 | 4 | 1 | 1 |
MICROPAPILLAR | 5 | 4 | 3 | 2 | 2 |
COLLOID (GELATINOUS) | 1 | 1 | NA | NA | NA |
SIGNET CELLS | 0 | 1 | 0 | 1 | 1 |
Vessels (1) | |||||
GLOMERULOID | 3 | 4 | 0 | 1 | 1 |
THIN | 4 | 3 | 3 | 1 | 1 |
NO | 20 | 20 | 7 | 8 | 8 |
Average stromal percentage | 24 ± 12.39 | 14 ± 8.95 | 22 ± 12 | 15 ± 7 | 10 ± 7 |
Average necrosis percentage | 21 ± 20 | 15 ± 13 | 21 ± 20 | 11 ± 9 | 23 ± 16 |
Markers (1) | |||||
SYNAPTOPHYSIN | 4 | 1 | 1 | 1 | 0 |
TTF-1 | 16 | 9 | 6 | 4 | 4 |
P40 | 2 | 2 | 2 | 2 | 2 |
VIMENTIN | 7 | 12 | 4 | 6 | 8 |
KI67 | 20 | 20 | 9 | 9 | 9 |
