Table 2 Inter-study reproducibility as evaluated by the absolute difference, coefficient of variation (COV) (expressed in %) and interclass correlation (ICC) between results from the first (CMR1) and second (CMR2) cardiac magnetic resonance exams, during isoflurane (IF) and pentobarbital (P) anesthesia.

From: Test-retest reproducibility of cardiac magnetic resonance imaging in healthy mice at 7-Tesla: effect of anesthetic procedures

 

Group IF

Group P

CMR1

CMR2

Absolute difference

COV

ICC [95%CI] (p)

CMR1

CMR2

Absolute difference

COV

ICC [95%CI] (p)

p

LVM (µg)

83.55 (7.22)

87.26 (13.67)

8.10 (8.58)

8.64 (8.36)

0.449 [−0.179–0.825] (0.074)

81.10 (8.75)

83.95 (11.35)

9.68 (7.58)

10.62 (7.42)

0.279 [−0.437–0.794] (0.219)

0.689

LVEDV (µL)§

53.92 (5.58)

54.20 (7.14)

3.96 (2.49)

7.00 (4.28)

0.737 [0.273–0.927] (0.003)

62.54 (20.53)

62.03 (8.28)

14.07 (10.30)

19.04 (12.62)

0.380 [−0.341–0.832] (0.142)

0.008

LVESV (µL)

16.15 (4.03)

15.84 (5.11)

2.40 (1.97)

12.97 (9.64)

0.779 [0.361–0.939] (0.002)

19.67 (12.58)

18.46 (8.30)

14.28 (9.35)

50.26 (19.73)

−0.349 [−0.807–0.406] (0.824)

0.001

LVEF (%)

70.23 (5.56)

71.12 (6.71)

3.82 (2.55)

5.36 (3.62)

0.729 [0.256–0.924] (0.004)

70.46 (10.26)

70.07 (14.05)

15.51 (11.99)

19.43 (15.06)

−0.324 [−0.797–0.429] (0.805)

0.008

RVEDV (µL)§

21.75 (5.95)

20.61 (3.73)

6.57 (3.04)

26.21 (10.32)

−0.089 [−0.638–0.536] (0.601)

36.64 (10.95)

35.25 (8.00)

11.56 (7.22)

26.13 (13.49)

−0.040 [−0.661–0.638] (0.535)

0.064

RVESV (µL)§

6.86 (2.81)

5.37 (2.30)

3.00 (2.64)

37.09 (24.43)

−0.123 [−0.658–0.511] (0.640)

15.20 (12.36)

13.86 (5.03)

9.55 (7.65)

42.98 (15.82)

0.157 [−0.535–0.741] (0.332)

0.022

RVEF (%)§

68.68 (10.05)

73.40 (11.81)

12.54 (8.84)

15.96 (9.74)

0.052 [−0.546–0.630] (0.433)

62.24 (19.22)

60.11 (13.13)

16.77 (11.63)

25.26 (18.61)

0.225 [−0.482–0.771] (0.267)

0.393

Ecc base§

−9.94 (2.80)

−10.33 (2.98)

2.85 (2.48)

45.13 (56.66)

0.143 [−0.545–0.734] (0.346)

−13.05 (3.75)

−12.64 (1.81)

2.67 (3.66)

23.64 (32.53)

0.539 [−0.151–0.885] (0.056)

0.912

Ecc apex§

−12.69 (2.85)

−11.86 (3.18)

3.80 (3.67)

55.12 (72.01)

−0.599 [−0.895–−0.103] (0.958)

−15.77 (2.35)

−14.70 (2.84)

2.52 (2.71)

18.25 (18.46)

0.462 [−0.250–0.860] (0.093)

0.505

Err base

5.05 (1.96)

7.10 (2.54)

3.01 (2.90)

32.62 (25.46)

−0.438 [−0.841–0.314] (0.833)

4.88 (4.00)

4.33 (2.14)

2.12 (1.85)

28.99 (19.22)

0.330 [−0.391–0.813] (0.179)

0.544

Err apex

7.38 (1.99)

4.91 (2.06)

3.29 (2.21)

40.35 (22.49)

0.449 [−0.845–0.301] (0.890)

6.47 (3.24)

7.58 (2.87)

4.56 (3.29)

50.42 (35.89)

0.447 [−0.268–0.855] (0.101)

0.387

Ell§

−10.65 (2.79)

−10.43 (2.24)

2.93 (3.55)

52.74 (90.08)

−0.758 [−0.948–−0.258] (0.994)

−14.08 (1.90)

−12.28 (2.13)

2.48 (2.10)

20.53 (15.04)

0.234 [−0.475–0.775] (0.259)

0.799

  1. Data are the mean (SD) except for ICC [95% interval confidence] (p). Comparison of inter-study COV between groups IF and P. §Indicates CMR parameters that are different (p < 0.05) between groups IF and P (pooled data from CMR1 and CMR2).