Figure 1

Proteome profiles of control and infected CSF samples. For each sample, protein discovery analysis was performed on a fixed volume of CSF from control (n = 12) and infected individuals (n = 16). (Panel a) Box plots analysing the number of protein groups obtained in control (blue) and infected (red) samples. Top and bottom of the box represent the 75% (Q3) and 25% (Q1) percentile, the line inside the box represents the median and whiskers define 1.5 times the interquartile range from the box. (Panel b) Number of host and pathogen proteins identified per sample. Each column expresses the number of human proteins identified in the sample (green) and the number of S. pneumoniae proteins (orange).