Figure 5
From: Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1
Recognition of the residue at the subsite −3 in substrate peptides. Interaction between human TPST1 and the residue at the −3 position in (a) C4P5Y5 and (b) the gastrin peptide productive form. (c) Interaction between human TPST1 and the sulfated tyrosine residue at the subsite −3 in the C4P5Y5 model peptide. The sulfotyrosine residue at the subsite −3 in C4P5Y5 is recognized by human TPST1 through electrostatic and hydrophobic interactions. Hydrogen bonds are depicted as orange dotted lines.
