Table 5 Performance comparison of several prediction tools based on the PhosPlus_set.
Kinase | Method | Accuracy | Sensitivity | Specificity | Precision | Recall | F-Score | MCC | AUC |
|---|---|---|---|---|---|---|---|---|---|
CDKs | KinasePhos | 86.6 | 65.2 | 86.9 | 5.8 | 65.2 | 10.6 | 0.195 | 0.777 |
PPSP | 91.0 | 74.1 | 91.2 | 9.4 | 74.1 | 16.8 | 0.261 | 0.838 | |
GPS | 84.4 | 78.0 | 84.5 | 5.8 | 78.0 | 10.9 | 0.206 | 0.881 | |
Musite | 88.9 | 77.1 | 89.0 | 8.0 | 77.1 | 14.4 | 0.242 | 0.886 | |
PhosphoPredict | 94.2 | 77.1 | 94.4 | 14.5 | 77.1 | 24.4 | 0.330 | 0.904 | |
CK2 | KinasePhos | 89.2 | 51.2 | 90.0 | 9.4 | 51.2 | 16.0 | 0.229 | 0.714 |
PPSP | 93.1 | 49.4 | 94.0 | 14.4 | 49.4 | 22.3 | 0.274 | 0.838 | |
GPS | 94.1 | 50.0 | 95.0 | 17.0 | 50.0 | 25.4 | 0.298 | 0.821 | |
Musite | 96.4 | 41.6 | 97.5 | 25.5 | 41.6 | 33.1 | 0.331 | 0.809 | |
PhosphoPredict | 91.9 | 50.6 | 92.8 | 12.5 | 50.6 | 20.1 | 0.259 | 0.727 | |
PKA | KinasePhos | 90.4 | 61.6 | 90.9 | 11.1 | 61.6 | 18.9 | 0.264 | 0.775 |
PPSP | 90.2 | 73.3 | 90.5 | 12.5 | 73.3 | 21.3 | 0.298 | 0.836 | |
GPS | 85.3 | 80.1 | 85.4 | 8.9 | 80.1 | 16.0 | 0.256 | 0.880 | |
Musite | 88.9 | 70.4 | 89.2 | 10.8 | 70.4 | 18.7 | 0.273 | 0.877 | |
PhosphoPredict | 91.1 | 80.5 | 91.3 | 14.0 | 80.5 | 32.7 | 0.327 | 0.896 | |
PKC | KinasePhos | 81.8 | 49.4 | 82.3 | 4.0 | 49.4 | 7.4 | 0.155 | 0.677 |
PPSP | 83.8 | 58.8 | 84.2 | 5.3 | 58.8 | 9.7 | 0.183 | 0.734 | |
GPS | 82.1 | 56.8 | 82.7 | 6.6 | 56.8 | 11.8 | 0.203 | 0.785 | |
Musite | 86.7 | 52.3 | 87.2 | 5.8 | 52.3 | 10.4 | 0.183 | 0.798 | |
PhosphoPredict | 87.8 | 57.2 | 88.3 | 6.8 | 57.2 | 12.2 | 0.203 | 0.826 |
