Figure 5
Cisplatin-resistance of osteosarcoma cells is promoted by TERT in vivo. (A) BALB/C nude mice with transfected xenograft tumors of 500 mm3 were given 5 mg/kg of cisplatin at embedded intervals of 4 days for 4 weeks. TERT-overexpressing xenograft tumors showed more resistant to cisplatin treatment. Data are represented as mean ± SEM *p < 0.05. (B,C) Tumor burden were assessed at time of death (8 weeks). Results expressed as mean ± 95% confidence intervals. n = 6 *p < 0.05. (D) Proteins were extracted from tumor burden. Apoptotic-related proteins expression were then assessed by Western blot analysis. β-actin was used as a leading control.
