Figure 1 | Scientific Reports

Figure 1

From: Cell-cycle arrest in mature adipocytes impairs BAT development but not WAT browning, and reduces adaptive thermogenesis in mice

Figure 1

Transgenic expression of p27 driven by the aP2 promoter did not affect WAT development but suppressed BAT development. (A) There were no differences in body weight between 12-week-old WT and aP2-p27 Tg mice. (B–D) Tissue weights (C) and representative examples of the gross (B) and histological (D) appearance show that inguinal and peri-gonadal WAT (I-WAT and G-WAT) in Tg mice is highly similar to I-WAT and G-WAT in WT mice. Conversely, interscapular BAT in Tg mice was reduced in size and volume but had normal histological features, compared to BAT in WT mice (n = 5 per group, Student’s t-test, *p < 0.05). (E) Measurement of the expression of p27Kip1 and p57Kip2 proteins showed the induction of p27 protein in the fat tissue of Tg mice (n = 5 per group, Student’s t-test, *p < 0.05).

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