Table 3 MR-IVW estimates for all phenotypes assumed to causally affect the apoA-IV concentrations. Here, the phenotypes act as exposures and apoA-IV as the outcome. A p-value smaller than 0.05/8 = 0.00625 is considered to be significant (marked in bold).

From: Evaluating the Causal Relation of ApoA-IV with Disease-Related Traits - A Bidirectional Two-sample Mendelian Randomization Study

Phenotype (exposure)

Causal effect of phenotype on apoA-IV

All SNPs

Removing SNP rs964184 for lipids

No. of SNPs

Beta*

95% CI*

P-value

No. of SNPs

Beta*

95% CI*

P-value

Lipid traits

HDL-C, unadjusted

71

0.0341

[0.0142, 0.0540]

0.0008

70

0.0271

[0.0067, 0.0474]

0.0091

HDL-C, adjusted for LDL-C and TG (multivariable MR)

71

0.0195

[−0.0084, 0.0475]

0.1706

70

0.0262

[−0.0018, 0.0542]

0.0672

LDL-C, unadjusted

58

−0.0376

[−0.0572, −0.0179]

0.0002

57

−0.0320

[−0.0519, −0.0121]

0.0016

LDL-C, adjusted for HDL-C and TG (multivariable MR)

58

−0.0225

[−0.0441, −0.0010]

0.0406

57

−0.0259

[−0.0480, −0.0039]

0.0213

TG, unadjusted

40

−0.0600

[−0.0834, −0.0366]

4.8e-07

39

−0.0498

[−0.0776, −0.0220]

0.0004

TG, adjusted for HDL-C and LDL-C (multivariable MR)

40

−0.0597

[−0.0962, −0.0232]

0.0014

39

−0.0487

[−0.0883, −0.0090]

0.0161

Kidney function

eGFR

53

−0.3890

[−0.5367, −0.2413]

2.4e-07

    

Adiposity-related parameters

BMI

77

0.0067

[−0.0266, 0.0400]

0.6946

    

WHR

40

0.0761

[0.0093, 0.1429]

0.0255

    

Fasting Glucose

Fasting Glucose

36

0.0146

[−0.0364, 0.0656]

0.5742

    
  1. *In log(apoA-IV) per change in SD for the lipid and obesity traits, in log(apoA-IV) per change in log(eGFR) for kidney function, in log(apoA-IV) per change in mmol/L for fasting glucose.
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