Figure 9 | Scientific Reports

Figure 9

From: Arsenic exposure impels CD4 commitment in thymus and suppress T cell cytokine secretion by increasing regulatory T cells

Figure 9The alternative text for this image may have been generated using AI.

Schematic representation of arsenic-induced Treg cells mediated immnosuppression. Exposure to arsenic promoted commitment of DP cells into CD4+ T cells in thymus. Simultaneously arsenic enhanced differentiation of splenic CD4+ T cells into Treg cells. Increased Treg cells secreted high amount of TGF-β which subsequently inhibited Th1 and Th2 related cytokines production thereby leading to immunosuppression.

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