Table 1 Time constants and area of the open and shut time histogram fits with Hidden Markov models.

From: A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

Time constants (ms) and areas (%)

Condition

Open time

Control (N = 7)

UBP684 (N = 7)

NR1c/NR2Ac (N = 4)

Ï„1

0.26 ± 0.03

0.86 ± 0.24*

0.73 ± 0.19*

Ï„2

2.76 ± 0.29

5.88 ± 1.08*

2.40 ± 0.25

a1

20 ± 3

16 ± 5

43 ± 17

a2

80 ± 3

84 ± 5

56 ± 17

Shut time

Ï„1

0.51 ± 0.05

0.42 ± 0.07

0.57 ± 0.12

Ï„2

5.06 ± 0.78

1.37 ± 0.18***

2.40 ± 0.32*

Ï„3

18.7 ± 1.9

4.63 ± 0.4***

11.3 ± 2.52*

Ï„4

62.3 ± 7.9

15.4 ± 1.3***

70.2 ± 13.2

Ï„5

1189 ± 190

895 ± 151

1060 ± 314

a1

22 ± 3

27 ± 4

48 ± 5**

a2

25 ± 3

43 ± 7*

36 ± 3*

a3

42 ± 4

26 ± 4*

14 ± 4**

a4

10 ± 2

4 ± 1*

1.7 ± 1*

a5

0.5 ± 0.1

0.2 ± 0.04*

0.2 ± 0.1

  1. The histograms were fitted with a model containing 5 closed states and 2 open states. Mean ± SEM are presented. Comparison was performed using unpaired t-test in relation to control. *P < 0.05, **P < 0.01 and ***P < 0.001.
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