Table 3 Comparison of various techchnologies for the detection of p24 antigen.

From: Femtogram Level Sensitivity achieved by Surface Engineered Silica Nanoparticles in the Early Detection of HIV Infection

S. No.

Method

P24 Concentration detected in pg/mL

Reference

1

Conventional Elisa

10–15

16

2

Inductively coupled plasma mass spectrometry based gold nanoparticle immunoassay

7.5

35

3

Europium nanoparticle based immunoassay

0.5

15

4

Capacitive Immunosensor

0.12

36

5

Microchip based Europium nanoparticle immunoassay

5

37

6

Single-molecule immunosorbent assay

0.1

38

7

ZnO nanoparticle based immunoassay

25

39

8

Fluorescent Silver nanoparticles immunoassay

10

40

9

P24 antigen detection assay with booster step

0.5

17

10

Immunofluorescent cytometric bead assay

0.4

41

11

Carbon Dots based immunoassay

20

42

12

Silica Nanoparticle based immunoassay

0.02

Current Study