Figure 5
From: Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model
Gene ontology enrichment analysis of HIV-1 integration sites. (A,B) GO enrichment analysis of the HIV-1 integration sites in singleton (A) and expanded clones (B). (C) The GO enrichment analysis for in vitro integration sites is shown as a control. The numbers above the graphs represent – log10 of binomial P-value. There were 69, 14, and 105 GO terms enriched significantly in singleton clones, expanded ones, and in vitro infection, respectively. Term names shown in red and green are associated with “Host-pathogen interaction” and “leukocyte and lymphocyte activation”, respectively. (D) Venn diagrams showing the similarities and differences of enriched GO terms between each data set. For comparison, top 14 term names were selected from each data set.
