Figure 4 | Scientific Reports

Figure 4

From: Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1

Figure 4

Mutational landscape of UNG/SMUG1/MSH2 triple knockout tumour. Whole genome sequencing was performed to assess the mutational profiles in tumour arising spontaneously in UNG/SMUG1/MSH2 triple knockout mice. (a) Rainfall plots showing the distribution of mutations in tumours from two different mice (denoted 70781 or 79002) along each chromosome. (b,c) The types of base pair changes represented as the fraction of the total variant observed. (d,e) Trinucleotide plots summarising the sequences surrounding each variant normalised to genomic trinucleotide occurrence. The sequence context of all mutations occurring at C:G base pairs is magnified below.

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