Figure 5 | Scientific Reports

Figure 5

From: ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

Figure 5

Effect of fasudil on ROCK-1 and ROCK-2 cellular distribution in diabetic RPE cells. Double staining ROCK-1 or ROCK-2 with Phalloidin on RPE cell flatmounts showed that Fasudil relocates ROCK-1 (a,b) from the membrane the cytoplasm in the Fasudil treated GK rat consistent with their inactivation and that it did not change the membrane distribution of ROCK-2 but induced an increased nuclear and perinuclear localization of ROCK-2 (g,j). (n = 5 per experiment). Scale bar = 10 µm.

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