Figure 6 | Scientific Reports

Figure 6

From: ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

Figure 6

Effect of intravitreal Fasudil on RPE cell layer morphology. (A) Phalloidin-stained actin on flat-mounted RPE from GK rat treated in vivo with vehicle (GK-V) or with fasudil (GK-F). Polydispersed size of RPE with apical constriction and stress fibers in GK-V rats (b) is reverved in GK-F rats (c). Scale bar = 10 µm. (B) boxplot summarizing the distribution of small cells in control rats (WS) and in diabetic rats (GK) treated by Fasudil (F) or vehicle (V). The RPE of GK Fasudil treated rats had significantly less small cells than the RPE of GK vehicle treated rats, suggesting less cellular constriction (n = 7 per experiment). ***p value < 0.001.

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