Figure 9
Effect of fasudil on retinal hypoxia. (A) Pimonidazole and lectin staining on flat-mounted retina from vehicle and fasudil treated rats. In hypoxic area stained with pimonidazole in the vehicle treated rats, lectin-labeled vessels appear constricted and irregular (a,b). Reduced hypoxic area observed in fasudil treated rats correspond to improved capillaries morphology (c) Magnification ×6. (B) Quantification of hypoxic aea shows that fasudil induces a significant reduction of hypoxic retinal surface ratio.
