Figure 2
From: Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein
Expression from ddr-2 and tph-1 occurs in distinct populations of neurons. (A) Location of ddr-2 expressing neurons (red) and tph-1 expressing neurons (green), all neurons are bilaterally symmetrical apart from RIH. Neurons depicted with connections in the nerve ring (NR) are ADF, AIM, RIH, HSN and PVP. Not all ddr-2 expressing neurons with connections to the NR are depicted. (B) L4 worm expressing ddr-2::mCherry, expression is evident in neurons in the head region as well as PVP neurons and the ventral nerve cord (VNC). (C–E) Adult worms expressing tph-1::mCherry, expression is visible exclusively in serotonergic neurons. (F–G) Confocal images of L4 worm (F) and the head region of a 1 day old adult worm (G) expressing ddr-2::mCherry and tph-1::GFP. Orthogonal view of images confirms there is no co-expression of mCherry or GFP reporters in any neurons. See also supplementary video 1.
