Figure 1
From: Interferon-alpha treatment rapidly clears Hepatitis E virus infection in humanized mice
Higher viral loads in HEV gt1 compared to HEV gt3 infected mice despite similar degrees of human chimerism. Comparison of peak HEV RNA levels as measured by qRT-PCR in serum (a) and in feces (b). At sacrifice viral titers of HEV gt3 and gt1 infected mice were compared in bile (c, n = 7 and n = 6, respectively) and in liver (d). Human albumin levels were determined in mouse serum to quantify degree of chimerism at euthanasia (e). *P < 0.05, n = 20 for HEV gt3 and n = 10 for HEV gt1 (a,b,d,e). Data are pooled from 2, 6, and 14 weeks infection experiments. Red dots indicate mice who received a diluted HEV inoculum (a–d).
