Figure 4
Estrogen receptors were involved in BPA-induced APP, BACE-1 and p-tau expressions. (A) ICI182780 inhibited the BPA-induced expressions of APP and BACE-1 in PC-12 cells. (C) ICI182780 inhibited the BPA-induced expression of p-tau in PC-12 cells. (E) G15 inhibited the BPA-induced expressions of APP and BACE-1 in PC-12 cells. (G) G15 inhibited the BPA-induced expression of p-tau in PC-12 cells. (B,D,F,H) GAPDH levels were assessed in parallel and served as controls. Mean values ± SEMs are representative of three independent isolations and three independent samples. Significant differences between the treatment groups and the control group were determined via one-way ANOVA and the LSD Dunnett comparison procedure. (*P < 0.05, **P < 0.01, ***P < 0.001 compared with the control group).
