Figure 3
From: Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides
In vivo evaluation of aptamer neutralization properties. (a) Time of death of mice induced by 0.5 µg toxin/g mouse b.w. as a function of D7 aptamer concentration. t = 0 min toxin injection (s.c. or i.p.), t = 1 min aptamer injection (i.v.). (b) Mice survival as a function of i.v.-injected D7 aptamer concentration. (c) Lack of effect of scramble oligonucleotides on αC-conotoxin PrXA-mediated death. (d) Lack of effect of D7, D3 and A5 aptamers on waglerin 1-mediated mice death.
