Figure 4 | Scientific Reports

Figure 4

From: Shedding Light on Alzheimer’s β-Amyloidosis: Photosensitized Methylene Blue Inhibits Self-Assembly of β-Amyloid Peptides and Disintegrates Their Aggregates

Figure 4

Photo-excited MB reduces the brain vacuolization in adult Drosophila. (a–d) Representative haematoxylin and eosin staining of adult head sections in AD model flies (elav > Aβ42) with or without 100 nM MB treatment under dark and red LED light conditions. Arrows indicate vacuole phenotypes in aged fly head. Scale bar: 20 μm. (e) Quantification of the vacuole size in adult head sections in AD model flies (elav > Aβ42) with or without MB treatment under dark and red LED light conditions. Percentage of the area lost in the cell body areas are shown as the averages s.e.m. (n = 5–7 hemispheres). The error bars represent means s.e.m. Experiments were performed at least three times. *P < 0.05, **P < 0.01, ***P < 0.001. n.s. not significant.

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