Figure 1
RAGE inhibition improves arterial oxygenation and alveolar fluid clearance. (A) Arterial oxygen tension (PaO 2 )/inspiratory oxygen fraction (FiO 2 ) in uninjured, untreated mice (Sham group), acid-injured animals (HCl group), acid-injured animals treated with sRAGE (HCl + recombinant sRAGE group) or with anti-RAGE monoclonal antibody (HCl + anti-RAGE mAb group)(n = 4–6 for each time-point). (B) Measurement of net alveolar fluid clearance (AFC) rate as a marker of epithelial function in acid-injured animals (HCl), acid-injured animals treated with sRAGE (HCl + recombinant sRAGE) or with anti-RAGE mAb (HCl + anti-RAGE mAb) (n = 4–6 for each time-point). As no difference was observed between sham animals at all time points; the results from sham mice were mixed for analyses (left bar of the X-axis). Values are reported as means ± standard deviations. **P < 10−2; ***P < 10−3; ****P < 10−4 versus sham controls; ###P < 10−3; ####P < 10−4 versus acid-injured animals.
