Figure 1
From: Genuine antiplasticizing effect of water on a glass-former drug
Effect of water on the glass transition temperature. (a) DSC scans for different water molar fractions x of binary prilocaine/water mixtures, measured upon heating at 8 K/min right after aging during 1 hour at 215.2 K. Inset: molecular structure of prilocaine. (b) Onset T g values for prilocaine as a function of water concentration (data corresponding to the thermograms in (a)). (c) Normalized glass transition temperatures for binary water-solute systems. Prilocaine: this work. T g values for other systems are described with the Gordon-Taylor equation (see Supplementary information) based on the T g values reported for sorbitol and for phospholipids DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) and DOPE (1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine). The corresponding parameters of the Gordon-Taylor equation are provided in Table S1 of the Supplementary information.
