Figure 2 | Scientific Reports

Figure 2

From: Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer

Figure 2

Growth in BALB/c mice (n = 5–6 per group) of primary tumors induced by the implantation of 4T1, 4T1luc2 and 4T1lucD6 cells (see Methods for description). Growth curves obtained by MRI visualize average tumor volume in cubic mm, with STDV (A); Growth of primary tumors induced by implantation of 4T1luc2 and 4T1lucD6 cells monitored by bioluminescent imaging; curves depict an average photon flux from the tumor per sec, with STDV (B); Statistical comparison of the tumor sizes evaluated by MRI (C). Median size of 4T1lucD6 tumors is significantly lower (p = 0,017), and of 4T1luc2 tumors tend to be lower than of 4T1 tumors, although the difference is not significant (p = 0,17). Day of implantation is counted as day 0. Statistical comparisons are done using Kruskal Wallis and Mann-Whitney tests (Statistica AXA 10.0).

Back to article page