Figure 6 | Scientific Reports

Figure 6

From: Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer

Figure 6The alternative text for this image may have been generated using AI.

Bone metastases formed by 4T1 (A–D) and 4T1luc2D6 (E–H) tumors at week 4 after implantation visualized by the combination of MRI, micro-CT and optical imaging. The T2-weighted MRI of a mouse with a 4T1 carcinoma, coronary section, the arrow indicates a metastasis in the vertebral body (A); Targeted high-resolution micro-CT of the same mouse with a fragment of 3D reconstruction, the arrow indicates the focus of osteolysis of the vertebral body (B); Micro-CT of a mouse with a 4T1 carcinoma on day 28 after implantation, the arrow indicates a osteolytic lesion by metastasis of the distal epiphysis of the right femur (C); Micro-CT of a 4T1 mouse with a metastasis in the region of the right knee-joint, the areas subjected to densitometry are highlighted (D); Targeted micro-CT of a 4T1luc2D6 mouse, the arrow indicates the metastasis in the distal epiphysis of the right femur (E,F); 4T1luc2D6 metastasis in the vertebral body (G) and the lower third of the left femur (H) visualized by bioluminescent imaging.

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