Figure 6 | Scientific Reports

Figure 6

From: Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer

Figure 6

Bone metastases formed by 4T1 (A–D) and 4T1luc2D6 (E–H) tumors at week 4 after implantation visualized by the combination of MRI, micro-CT and optical imaging. The T2-weighted MRI of a mouse with a 4T1 carcinoma, coronary section, the arrow indicates a metastasis in the vertebral body (A); Targeted high-resolution micro-CT of the same mouse with a fragment of 3D reconstruction, the arrow indicates the focus of osteolysis of the vertebral body (B); Micro-CT of a mouse with a 4T1 carcinoma on day 28 after implantation, the arrow indicates a osteolytic lesion by metastasis of the distal epiphysis of the right femur (C); Micro-CT of a 4T1 mouse with a metastasis in the region of the right knee-joint, the areas subjected to densitometry are highlighted (D); Targeted micro-CT of a 4T1luc2D6 mouse, the arrow indicates the metastasis in the distal epiphysis of the right femur (E,F); 4T1luc2D6 metastasis in the vertebral body (G) and the lower third of the left femur (H) visualized by bioluminescent imaging.

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