Table 1 Characteristics of the metastatic potential of 4T1 and 4T1luc2D6 cells in the orthotopic breast cancer model evaluated by BLI and confirmed by MRI.

From: Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer

Mice (n = 20) implanted with

Total metastases

Lymph nodes

Lungs

Spleen

Liver

Bones

Brain

Average n, number of metastases per mouse

4T1

54

19

15

7

6

4

3

11.4 ± 2.1

4T1luc2D6

31

17

7*

3

2(*)

2

0

4.5 ± 0.6**

  1. **p < 0,00001 (t-test); *p < 0.05 and (*)p < 0.1 (U-test).
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