Figure 2
MiR-33b regulates eosinophil influx and lung inflammation in response to CRE. (A) Inflammation in pulmonary sections of the PBS and CRE groups of mice that were transfected with miR-33b or miR-NC. Representative images of the central airways stained with hematoxylin and eosin (HE) and periodic acid-Schiff (PAS) staining. (B) Histology scores of the HE staining. (C) Cellular inflammation, as reflected by the total cell number and differentiated leukocyte cell numbers in the BALF. (D) Airway hyper-responsiveness to methacholine (Mch) was analyzed in the various groups. (E) Serum levels of cockroach allergen-specific IgE and IgG1 (F) Th2 cytokines IL-4, -5 and -13 in the BALF. The data are representative of three independent experiments (n = 4–6 mice/group). The data are presented as the means ± SEM. **P < 0.01, ***P < 0.001.
