Figure 1

Effect of Hyp-GQDGLAGPK on tear production in the experimental dry eye mouse model. The tear volumes of the Hyp-GQDGLAGPK, cyclosporine, diquafosol, and sodium hyaluronate groups were measured at baseline, after 10 days of desiccation stress (DS 10d), and after treatment for 3, 5, 7, and 10 days. The quantitative data are presented as the means ± SD. The results are statistically significant by analysis of variance with the Tukey test at *p < 0.05 compared with baseline, # p < 0.05 compared with DS 10d and † p < 0.05 vs. corresponding value in the normal saline group. Baseline = before desiccation stress; DS 10d = immediately after desiccation stress for 10 days; Tx 3d, Tx 5d, Tx 7d and Tx 10d = 3, 5, 7 and 10 days after treatment with Hyp-GQDGLAGPK, cyclosporine, diquafosol, and sodium hyaluronate eye drops, respectively.