Figure 8 | Scientific Reports

Figure 8

From: Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals

Figure 8

AA, AG and GG individuals respond to vitamin D and produce regulatory cytokines. CD4+CD25− T cells were activated in vitro with aCD3 antibody and CHO-CD80 cell line in the presence or absence of 1,25(OH)2D3. At day 3, cell-free supernatant was collected and tested for the presence of secreted cytokines. Data show the ratio of IL-10 versus pro-inflammatory cytokines IFNγ, IL-17, IL-2, IL-9, IL-21 and IL-22. **p < 0.01, ***p < 0.001 using Wilcoxon matched-pairs signed rank test.

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