Figure 7
From: Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
Isoflurane accentuates glutamatergic transmission and plasticity in the hippocampus. (A) Slope of field excitatory postsynaptic potential (fEPSP) recorded in the area CA1 plotted as a function of presynaptic fiber volley (PSFV) amplitude recorded in slices from mice treated with isoflurane (30 min) at 24 hours before (n = 12 slices/8 mice) and in control animals (n = 10 slices/7 mice) (one-way ANOVA: F1,20 = 1.314, p = 0.0479). (B) Paired-pulse facilitation induced by two consecutive stimuli with interpulse interval (IPI) between 10 and 200 msec was not different between the groups (F1,10 = 0.354, p = 0.564). n = 9 slices/8 mice for isoflurane group and n = 10 slices/7 mice for control group. Statistical analysis was done using one-way ANOVA. (C) Long-term potentiation (LTP) induced by high-frequency stimulation (HFS, 100 Hz/1 s) is significantly enhanced in slices from isoflurane treated animals (two-way ANOVA: F1,64 = 7.91, p = 0.000896; n = 8 slices/8 mice for isoflurane group and n = 8 slices/7 mice for control group). Representative fEPSPs taken before and 30 min after the HFS are shown in the insets (control = black, isoflurane = grey).
