Table 1 Literature overview context conditioning in humans.

From: Context conditioning in humans using commercially available immersive Virtual Reality

Publication

Paradigm

Context manipulation

Measures: During task

US exp.

fMRI

Before and after task

Anxiety

STAI-S

After task

FPS

SCR

SCL

Arousal

Affect/Valence

PANAS

Contingency

Kroes et al., current submission

CTX

iVR, 1a

✓

✓

   

✓

✓

   

✓

Troger et al.74.*

CTX

iVR, 2b

✓

✓

   

✓

✓

✓

✓

✓

✓

Glotzbach59

CTX

iVR, 2b

✓

 

✓

  

✓

✓

✓

  

✓

Glotzbach-Schoon et al.56

CTX

iVR, 2b

✓

 

✓

    

✓

  

✓

Glotzbach-Schoon et al.92

CTX

iVR, 2b

✓

 

✓

    

✓

✓

✓

✓

Glotzbach-Schoon et al.58

CTX

iVR, 2b

✓

 

✓

✓

   

✓

✓

✓

✓

Andreatta et al.40

CTX

iVR, 2b&c

    

✓

  

✓

✓

✓

✓

Andreatta et al.48

CTX

iVR, 2b

✓

 

✓

  

✓

✓

✓

 

✓

✓

LaBar et al.24

Cue in CTX

Test room

 

✓

         

Neuman et al.26

Cue in CTX

Test room

   

✓

       

Schiller et al.44

Cue in CTX

Test room

 

✓

         

Huff et al.27

Cue in CTX

Test room

 

✓

         

Huff et al.35

Cue in CTX

Full iVR, 3

 

✓

 

✓

       

Muhlberger et al.75

Cue in CTX

iVR, 2b

✓

      

✓

   

Dunsmoor et al.37

Cue in CTX

VR, 3b

✓

          

Ahs, et al.39

Cue in CTX

VR, 3c

 

✓

 

✓

   

✓

   

Baas et al.30

Cue in CTX

2D Movie

✓

      

✓

  

✓

Baas et al.76

Cue in CTX

2D Movie

   

✓

   

✓

  

✓

Grillon et al.77

Cue in CTX

2D Movie

✓

      

✓

   

Alvarez et al.41

Cue in CTX

2D Movie

✓

✓

     

✓

   

Alvarez et al., 200894

Cue in CTX

2D Movie

✓

          

Grillon et al., 200895

Cue in CTX

2D Movie

✓

          

Armony et al.28

Cue in CTX

2D Static

 

✓

  

✓

      

Milad et al.29

Cue in CTX

2D Static

 

✓

         

Kalisch et al.78

Cue in CTX

2D Static

 

✓

  

✓

      

Milad et al.43

Cue in CTX

2D Static

 

✓

  

✓

      

Marschner et al.79

Cue in CTX

2D Static

 

✓

 

✓

✓

      

Neumann et al.80

Cue in CTX

2D Static

 

✓

 

✓

       

Pace-Schott et al.81

Cue in CTX

2D Static

 

✓

         

Rougemont-Bucking et al.82

Cue in CTX

2D Static

 

✓

  

✓

      

Van Ast et al.83

Cue in CTX

2D Static

✓

✓

 

✓

  

✓

  

✓

 

Balooch et al.84

Cue in CTX

2D Static

✓

  

✓

       

Haaker et al.93

Cue in CTX

2D Static

 

✓

 

✓

✓

      

Haaker et al.86***

Cue in CTX

2D Static

✓

✓

        

✓

Londsdorf et al., 201494

Cue in CTX

2D Static

✓

  

✓

       

Glenn et al., 201498

Cue in CTX

2D Static

✓

  

✓

 

✓

     

Londsdorf et al., 201585

Cue in CTX

2D Static

✓

 

✓

✓

       

Kastner et al.95**

Cue in CTX

2D Static

     

✓

✓

✓

   

Kroes et al.45

Cue in CTX

2D Static

 

✓

  

✓

     

✓

Haaker et al.86

Cue in CTX

2D Static

 

✓

 

✓

       

Sjouwerman et al.87

Cue in CTX

2D Static

✓

✓

   

✓

    

✓

Hermann et al.88

Cue in CTX

2D Static

 

✓

  

✓

      

Kuhn et al.89

Cue in CTX-ITI

2D Static

✓

✓

✓

 

✓

 

✓

✓

   

Ameli et al.90

Cue in CTX-ITI

N/A

✓

    

✓

✓

 

✓

  

Grillon et al.91

Cue in CTX-ITI

N/A

✓

 

✓

  

✓

✓

    

Grillon et al.73

Cue in CTX-ITI

N/A

✓

      

✓

   
  1. Paradigm: CTX = context conditioning, conditioning paradigm where no other cues signal the onset of the unconditioned stimulus. Cue in CTX = cue in context, paradigm where specific cues signal the onset of the unconditioned stimulus dependent on the context in which they occur. Cue in CTX-ITI = Cue in context-inter trial interval, paradigm where specific cues signal the onset of the unconditioned stimulus and defensive responses during inter-trial intervals are taken as a index for context conditioned responses. Context manipulation: iVR = Immersive virtual reality, context manipulation is achieved using head-mounted virtual reality display where head movements are translated into changes in field of view. Test room = context manipulation is achieved by physically moving participants and testing them in different lab spaces. Full iVR = Full immersive Virtual Reality, context manipulation is achieved within room-sized cube (CAVE-like) where the environment is projected onto the walls, floor and ceiling and head movements are translated into changes in field of view. 2D movie = context manipulation is design in 3D but presented as a movie on a 2D computer screen or projected on a screen. 2D static = context manipulation is achieved by presenting a background image. N/A = not applicable, these studies do not manipulate context but take responses during inter-trial intervals as an index of context conditioned responses. *This study also measured heart rate during the task. **This study also measured EEG during the task. ***This study also measured fear ratings during the task. +This study assessed responses during inter-trial-intervals as a proxy for context conditioned responses. FPS = fear potentiated startle; SCR = skin conductance responses; SCL = skin conductance level; US exp. = unconditioned stimulus expectancy ratings; fMRI = functional magnetic resonance imaging; STAI-S = State-Trait Anxiety Inventory-S; PANAS – Positive Affect Negative Affect Scale. References: 24,25,26,27,28,29,30, 35, 38,39,40, 46, 48, 58, 59, 72, 74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95. We apologize for any possible mistakes in our assessment of publications or omission of literature.