Figure 2 | Scientific Reports

Figure 2

From: A novel missense variant in the nuclear localization signal of POU4F3 causes autosomal dominant non-syndromic hearing loss

Figure 2The alternative text for this image may have been generated using AI.

(a) The POU4F3 p.Lys328 indicated in red shading was located within the bipartite nuclear localization signal (NLS) in the POU homeodomain. The bipartite NLS was conserved across nine species. (b) The location of six reported POU4F3 missense variants and p.Lsy328Glu. POU-specific domain and POU homeodomain are indicated by black boxes. Two NLSs were indicated by red lines. (c) The predicted protein products of five reported POU4F3 frameshift variants. Boxes with slash indicate the new amino acid sequences after the frameshift.

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